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PubMed COVID-19 Clinical Care

41321 - 41330 of 44979 results found

All-atom simulations of the trimeric spike protein of SARS-CoV-2 in aqueous medium: Nature of interactions, conformational stability and free energy diagrams for conformational transition of the protein

Date
Friday, March 31, 2023 - 4:00 AM
Description
The spike protein of SARS-CoV-2 exists in two major conformational states, namely the 'open' and 'closed' states which are also known as the 'up' and 'down' states, respectively. In its open state, the receptor binding domain (RBD) of the protein is

School closures during COVID-19: an overview of systematic reviews

Date
Friday, March 31, 2023 - 4:00 AM
Description
CONCLUSIONS: School closures during COVID-19 had both positive and negative impacts. We found a large number of SRs and primary studies. However, confidence in the SRs was mostly low to very low, and the certainty of evidence was also mostly very low